Heart failure & cardiomyopathies
Subphenogroups of acute heart failure with preserved ejection fraction: comprehensive proteomics and pathway analysis
Authors' conclusion
Using a comprehensive plasma proteomics approach, our study identified distinct proteomic profiles of HFpEF phenogroups, which in turn suggest specific underlying biological processes. These profiles suggest the involvement of inflammatory activation, tissue injury and regenerative responses, immune modulation and systemic stress signalling as key components of HFpEF pathophysiology.
Study context
- Population
- Hospitalised patients with acute decompensated HFpEF with available proteomics datapatients with HFpEF with available proteomics data, of the overall cohort (N=1238)
- Participants
- 198 patients
- Comparison
- Proteomic patterns of HFpEF phenogroups identified through a machine-learning-based clustering model
Methodological detailsmulticentre prospective observational study, machine-learning-based clustering model, SomaScan assay V.4.1
- Multicentre prospective observational study
- Machine-learning-based clustering model
- SomaScan assay V.4.1
Primary result
As reported in the abstract
Plasma protein expression profiles
- Distinct protein expression profiles among the phenogroups, with ribonuclease 4, tax1-binding protein 1, regenerating islet-derived protein 3-gamma and alpha-1-antichymotrypsin being the most significant markers to specific identified phenogroups
Further findings
Pathway analysis
- Differences in immune response, autonomic activation, cellular homeostasis and tissue repair mechanisms across the phenogroups
Original publication
Subphenogroups of acute heart failure with preserved ejection fraction: comprehensive proteomics and pathway analysis. Heart. Published 1 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →