Arrhythmias & electrophysiology
Sudden Cardiac Death as First Manifestation of Cardiovascular Disease: A Nationwide Study of 54,028 Deaths
Authors' conclusion
The distribution of SCD cases is nearly equal between individuals with and without a history of CVD, although the risk remains higher in those with prior CVD. Future research should aim to uncover the distinct causes and mechanisms driving SCD in populations with a known CVD, as well as the general population.
Study context
- Population
- All Danish citizens; Sudden cardiac death (SCD) cases with and without a known history of cardiovascular disease (CVD)SCD cases identified
- Participants
- 6,851 participants
- Comparison
- SCD cases with and without a known history of CVD
- No history of CVDn = 3,046reference
- Outcome
- SCD cases without a history of CVD
Methodological detailsall deaths reviewed by ≥1 medical doctor to identify cases of SCD
- All deaths reviewed by ≥1 medical doctor to identify cases of SCD
Main finding
As reported in the abstract
No history of CVD
44.5%
3,046
Further findings
| Outcome | Incidence rate ratio (95% CI) | |
|---|---|---|
| SCD incidence, history of CVD vs no history of CVD, by ageHistory of CVDvs No history of CVDAged 0 to 19 years | 21.6 (5.2–66.7) | |
| SCD incidence, history of CVD vs no history of CVD, by ageHistory of CVDvs No history of CVDAged >90 years | 1.8 (1.7–1.9) | |
| 0.050.21520Incidence rate ratio (log scale) |
- SCD incidence, history of CVD vs no history of CVD, by age: The difference in SCD incidence between individuals with and without a history of CVD decreased with age
Incidence rates of SCD by age
- Incidence rates of SCD increased with age and were higher in cases with a history of CVD across all age groups
Odds of having a CVD before SCD
- Female sex, OR (lower odds)
- 0.66
- Living alone, OR (lower odds)
- 0.75
Original publication
Sudden Cardiac Death as First Manifestation of Cardiovascular Disease: A Nationwide Study of 54,028 Deaths. JACC Clin Electrophysiol. Published 5 February 2025. doi:10.
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