Long forms of cardiac troponin T for myocardial infarction diagnosis: the SuperTROPO study
Authors' conclusion
The long cTnT assay demonstrated good diagnostic performance in identifying MI in patients with elevated total cTnT levels, with the potential to improve the accuracy of MI diagnosis.
Study context
- Population
- ED patients with high-sensitivity cardiac troponin T (cTnT) above the upper reference limit (≥14 ng/L)205 (11.3%) with myocardial infarction (MI)
- Participants
- 1,811 patients
- Comparison
- Long cTnT vs total cTnT for MI identification
- Outcome
- Diagnostic value for type 1 MI or any MI
Methodological detailsconsecutive patients
- Consecutive patients
Performance
As reported in the abstract
Discrimination (AUC) for any MI and type 1 MI
| Test or model | AUC any MI | AUC type 1 MI |
|---|---|---|
| Long cTnT | .833 (95% CI .804-.863) | .839 (95% CI .807-.872) |
| Total cTnT | .782 (95% CI .744-.819) | .777 (95% CI .735-.819) |
AUC any MI
Long cTnT.833 (95% CI .804-.863)
Total cTnT.782 (95% CI .744-.819)
AUC type 1 MI
Long cTnT.839 (95% CI .807-.872)
Total cTnT.777 (95% CI .735-.819)
- Long cTnT vs Total cTnT: P < 0.001 — any MI and type 1 MI, both
Further findings
Type 1 MI in lowest long cTnT tertile (<3.7 ng/L)
- Type 1 MI in lowest tertile
- .7%
Reclassification and decision curve analyses
- Adding long cTnT to total cTnT provided additional value vs total cTnT alone
Original publication
Long forms of cardiac troponin T for myocardial infarction diagnosis: the SuperTROPO study. Eur Heart J. Published 5 December 2025. doi:10.
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