Association between troponin level and medium-term mortality in 20 000 hospital patients
Main finding · MortalityResult — go to the resultHazard ratio 1.76 95% CI 1.65–1.88Authors' conclusion
In a large, unselected hospital population, in 91.4% of whom there was no clinical indication for testing, cTnI concentration was independently associated with medium-term cardiovascular and non-cardiovascular mortality in the statistical model tested.
Study context
- Population
- Consecutive in-hospital and outpatient patients who had a blood test for any reason at a large teaching hospital, with hs-cTnI measured regardless of clinical indication18,282 (91.4%) no indication for cardiac troponin I (cTnI)
- Participants
- 20,000 participants
- Exposure
- cTnI above vs not above upper limit of normal (ULN)
- Outcome
- Medium-term mortality
- Follow-up
- Median 809 days
Methodological detailsconsecutive patients, single large teaching hospital, Mortality obtained via NHS Digital
- Consecutive patients
- Single large teaching hospital
- Mortality obtained via NHS Digital
Main finding
Mortality
Hazard ratio
1.76
95% CI 1.65–1.88
By group
log10 cTnI concentration
HR 1.76 (95% CI 1.65–1.88)
As reported in the abstract
- Overall deaths
- 2825 (14.1%)
Observational data: associations, not effects.
Further findings
Mortality, landmark analysis excluding deaths within 30 days
- Relationship between cTnI concentration and mortality persisted
Original publication
Association between troponin level and medium-term mortality in 20 000 hospital patients. Heart. Published 7 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →