Arrhythmias & electrophysiology
Surgical and transcatheter left atrial appendage closure in patients with atrial fibrillation and hypertrophic cardiomyopathy
Main findingResult — go to the resultHazard ratio 0.38 95% CI 0.17–0.88Authors' conclusion
Surgical and transcatheter LAAC was associated with a lower risk of haemorrhagic stroke and major bleeding.
Study context
- Population
- Patients with Hypertrophic Cardiomyopathy (HCM) and Atrial Fibrillation (AF), National Readmission Dataset287 transcatheter left atrial appendage closure (LAAC)
- Participants
- 71,980 patients
- Exposure
- LAAC vs no LAAC
- LAACn = 1,351
- Outcome
- Composite of:
- Ischaemic and haemorrhagic stroke
- TIA
- All-cause mortality
Methodological detailsinverse probability of treatment weighting
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
Hazard ratio
0.38
95% CI 0.17–0.88
P = 0.024
By group
LAACvs No LAAC
HR 0.38 (95% CI 0.17–0.88); P = 0.024
Observational data: associations, not effects.
Further findings
- LAAC trended towards lower risk of ischaemic stroke and all-cause mortality
Safety
| Outcome | LAAC | No LAAC | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Primary safety outcome: major bleeding and pericardial complications | 2.9% | 6.8% | 0.39 (0.23–0.66) | P = 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Primary safety outcome: major bleeding and pericardial complications
- Reduced major bleeding with LAAC
Original publication
Surgical and transcatheter left atrial appendage closure in patients with atrial fibrillation and hypertrophic cardiomyopathy. Europace. Published 5 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →