Survival After Myocardial Infarction According to Left Ventricular Function and Heart Failure Symptoms
Authors' conclusion
Reduced LVEF in the acute phase of AMI was associated with up to 20% 1-year mortality after discharge, substantially higher than in recent post-MI trials. Symptoms of HF during the index hospitalization were associated with worse outcomes in patients with preserved LVEF but contributed little additive risk for patients with reduced LVEF.
Study context
- Population
- Patients with acute myocardial infarction (AMI) registered in the Norwegian Myocardial Infarction Registry 2013–2022AMI patients (mean age 68.1 ± 12.9 years, 31% female)
- Participants
- 70,809 patients
- Exposure
- Symptomatic patients discharged alive vs asymptomatic, within each LV ejection fraction (LVEF) category
- Outcome
- Distribution of LVEF categories
Methodological detailsNorwegian Myocardial Infarction Registry 2013-2022, Kaplan-Meier survival curves, Life Table and multivariable Cox regression models
- Norwegian Myocardial Infarction Registry 2013-2022
- Kaplan-Meier survival curves, Life Table and multivariable Cox regression models
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Symptomatic HF, by LVEF category
Cumulative mortality rate · 1-year from discharge
Asymptomatic
Symptomatic
| Outcome | Adjusted hazard ratio (CI) | |
|---|---|---|
| Mortality in patients discharged aliveSymptomatic vs asymptomatic · preserved LVEF | 1.85 (1.70–2.02) | |
| Mortality in patients discharged aliveSymptomatic vs asymptomatic · mildly reduced LVEF | 1.33 (1.25–1.41) | |
| Mortality in patients discharged aliveSymptomatic vs asymptomatic · reduced LVEF | 1.15 (1.06–1.24) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Survival After Myocardial Infarction According to Left Ventricular Function and Heart Failure Symptoms. ESC Heart Fail. Published 18 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it