Heart failure & cardiomyopathies
Symptoms and signs in patients with heart failure: association with 3-month hospitalisation and mortality
Authors' conclusion
In the primary care HF population, routinely recorded cardiac and non-specific symptoms showed differential risk associations with hospitalisation and mortality.
Study context
- Population
- Patients with a new heart failure (HF) diagnosis in primary care, Clinical Practice Research Datalink, 1998–2020database cohort
- Participants
- 86,882 patients
- Comparison
- Symptoms and signs in 3-month history: cases vs matched controls
- Outcome
- All-cause, HF and non-CVD hospitalisation and mortality
- Follow-up
- 3 months
Methodological detailsdensity-based sampling, Controls could be included more than once and later become a case
- Density-based sampling
- Controls could be included more than once and later become a case
Main finding
As reported in the abstract
HF hospitalisation: adjusted associations of symptoms and signs (cases vs matched controls) · 3-month history
- Pulmonary oedema, adjusted OR
- 3.08; 2.52, 3.64 (95% CI)
- Shortness of breath, adjusted OR
- 2.94; 2.77, 3.11 (95% CI)
- Peripheral oedema, adjusted OR
- 2.16; 2.00, 2.32 (95% CI)
- Depression, adjusted OR
- 1.50; 1.18, 1.82 (95% CI)
- Anxiety, adjusted OR
- 1.35; 1.06, 1.64 (95% CI)
- Pain, adjusted OR
- 1.19; 1.10, 1.28 (95% CI)
Observational data: associations, not effects.
Further findings
Non-CVD hospitalisation: associations of symptoms (cases vs matched controls) · 3-month history
- Chest pain, OR
- 2.93; 2.77, 3.09 (95% CI)
- Fatigue, OR
- 1.87; 1.73, 2.01 (95% CI)
- General pain, OR
- 1.87; 1.81, 1.93 (95% CI)
- Depression, OR
- 1.59; 1.44, 1.74 (95% CI)
Original publication
Symptoms and signs in patients with heart failure: association with 3-month hospitalisation and mortality. Heart. Published 1 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →