Heart failure & cardiomyopathies
Systolic blood pressure time in target range and long-term outcomes in patients with ischemic cardiomyopathy
Authors' conclusion
In patients with ICM, the higher TTR was significantly associated with decreased risk of all-cause mortality, CV mortality and the composite outcome of all-cause mortality plus CV rehospitalization, regardless of whether the patient received coronary artery bypass grafting or medical therapy, and the level of baseline SBP.
Study context
- Population
- Patients with ischemic cardiomyopathy in the surgical treatment of ischemic heart failure trial; Systolic blood pressure (SBP) target range 110 to 130 mm Hgtrial enrolled 2,136
- Participants
- 1,194 patients
- Comparison
- SBP time in target range (TTR) quartiles
- Primary endpoint
- All-cause mortality
Primary result
As reported in the abstract
Estimate (95% CI)
Quartile 3 vs Quartile 4
adjusted HR 1.32(0.98–1.78)
Quartile 2 vs Quartile 4
adjusted HR 1.40(1.03–1.90)
Quartile 1 vs Quartile 4
adjusted HR 1.53(1.14–2.04)
Per 29.28% (1-SD) decrement in TTRsignificantly increased risk
HR 1.15(1.04–1.26)
Further findings
Cardiovascular (CV) mortality; composite of all-cause mortality plus CV rehospitalization; subgroups (CABG or medical therapy, baseline SBP)
- Similar results observed
Original publication
Systolic blood pressure time in target range and long-term outcomes in patients with ischemic cardiomyopathy. Am Heart J. Published 3 March 2023. doi:10.
Summarised from the published abstract; every number is checked against it