Heart failure & cardiomyopathies
Taking a Walk on the Heart Failure Side: Comparison of Metabolic Variables During Walking and Maximal Exertion
Authors' conclusion
The 6MWT can be a maximal effort especially in most severe HF patients
Study context
- Population
- Athletes, healthy subjects and heart failure (HF) patients of different severity, including left ventricular assist device (LVAD) carriers, who underwent both cardiopulmonary exercise testing (CPET) and 6MWT with oxygen consumption measurement
- Participants
- 186 athletes
- Exposure
- Metabolic variables during 6MWT vs CPET
- Athletesn = 16
- Healthyn = 40
- HFn = 115
- LVADn = 15
- Outcome
- Relationship between cardiorespiratory parameters during CPET and 6MWT
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
| Group | Value | % of peakV̇O2 during 6MWT | 6MWT-V̇O2 > CPET-peakV̇O2 |
|---|---|---|---|
| Athletes | 41.0 (range 35.0–45.8) ml/Kg/min | 63.5 [56.3-76.8] | 0 |
| Healthy | 26.2 (range 23.1–31.0) ml/Kg/min | 72.0 [57.8-81.0] | 1 (2.5%) |
| HF | 12.8 (range 11.1–15.3) ml/Kg/min | 95.5 [80.3-109] | 30 (26.1%) |
| LVAD | 15.2 (range 13.6–15.6) ml/Kg/min | 95.0 [92.0-99.0] | 1 (6.7%) |
Value
Athletes41.0 (range 35.0–45.8) ml/Kg/min
Healthy26.2 (range 23.1–31.0) ml/Kg/min
HF12.8 (range 11.1–15.3) ml/Kg/min
LVAD15.2 (range 13.6–15.6) ml/Kg/min
% of peakV̇O2 during 6MWT
Athletes63.5 [56.3-76.8]
Healthy72.0 [57.8-81.0]
HF95.5 [80.3-109]
LVAD95.0 [92.0-99.0]
6MWT-V̇O2 > CPET-peakV̇O2
Athletes0
Healthy1 (2.5%)
HF30 (26.1%)
LVAD1 (6.7%)
- CPET peak V̇O2 across groups
- P < 0.001
- 6MWT-V̇O2 associated with CPET-peakV̇O2, whole population
- R2 = 0.637
- Walked distance associated with CPET-peakV̇O2, whole population
- R2 = 0.533
- Associations significant in whole population but not in sub-groups; confirmed after adjustment for groups
- P ≤ 0.001
Observational data: associations, not effects.
Original publication
Taking a Walk on the Heart Failure Side: Comparison of Metabolic Variables During Walking and Maximal Exertion. ESC Heart Fail. Published 29 January 2024. doi:10.
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