Acute cardiac care & resuscitation
Targeted proteomic profiling of cardiogenic shock in the cardiac intensive care unit
An erratum to this article was published (Eur Heart J Acute Cardiovasc Care, 7 Aug 2025 ↗)
Authors' conclusion
In this pilot study of targeted proteomic profiling in CS, we identified nine biomarkers significantly associated with CS when cross-validated against non-shock controls including those with HF or isolated hypotension
Study context
- Population
- Patients admitted to a cardiac ICU, 2017–2020 (biorepository)
- Participants
- 239 patients
- Comparison
- Cardiogenic shock (CS) cases vs non-shock controls
- CSn = 69
- Non-shock controlsn = 170reference
- Outcome
- Circulating protein biomarkers associated with CS (Olink platform, 359 biomarkers)
Methodological detailspilot study, Bonferroni correction
- Pilot study
- Bonferroni correction
Main finding
As reported in the abstract
Biomarkers significantly associated with CS vs all controls after Bonferroni correction
63
17.7%
Biomarkers remaining significant when cross-validated vs isolated hypotension and HF controls (cathepsin D, FGF-21, FGF-23, GDF-15, IGFBP-1, NT-proBNP, osteopontin, OSMR, sST2)
9
Observational data: associations, not effects.
Further findings
Multi-marker model for CS diagnosis
- Biomarkers providing complementary information: sST2, FGF-23, CTSD, GDF-15
- 4
Original publication
Summarised from the published abstract; every number is checked against it