Temporal changes in coronary plaque as assessed by an artificial intelligence–based optical coherence tomography: from the first-in-human trial on DREAMS 3G scaffold
Authors' conclusion
The larger the fibrous tissue in the lesion at baseline, the larger the luminal loss seen at 6 and 12 M. Following the implantation of DREAMS 3G, favourable healing of the vessel coronary wall occurs as shown by a decrease in the lipid area and an increase in fibrous tissue.
Study context
- Population
- Patients treated with the DREAMS 3G scaffold, imaged by optical coherence tomography (OCT) pre- and post-implantation and at 6 and 12 M
- Participants
- 116 patients
- Comparison
- Baseline plaque composition vs luminal late loss; serial plaque changes baseline vs 6 and 12 M after DREAMS 3G
- Primary endpoint
- Impact of baseline plaque composition on DREAMS 3G luminal late loss; serial plaque changes (lipid, calcium, fibrous tissue)
- Follow-up
- 6 and 12 M
Methodological detailsartificial intelligence–based OCT analysis, serial imaging
- Artificial intelligence–based OCT analysis
- Serial imaging
Primary result
As reported in the abstract
- Larger minimum lumen area (MLA) differences at 12 M associated with significantly larger baseline fibrous tissue content
- P = 0.0003
- Reduction in lipid area vs pre-DREAMS 3G OCT at 6 M
- 24.8%
- Reduction in lipid area vs pre-DREAMS 3G OCT at 12 M
- 20.9%
- Lipid area reductions at 6 and 12 M, P
- P < 0.001
- Increase in fibrous tissue at 6 M
- 48.4%
- Increase in fibrous tissue at 12 M
- 36.0%
- Fibrous tissue increases at 6 and 12 M, P
- P < 0.001
Original publication
Temporal changes in coronary plaque as assessed by an artificial intelligence–based optical coherence tomography: from the first-in-human trial on DREAMS 3G scaffold. Eur Heart J Cardiovasc Imaging. Published 4 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →