Temporal Changes in Clinical Characteristics and Outcomes of Adults With Congenital Heart Disease
Study context
- Population
- Adults with CHD, classified by anatomic group (simple, moderate, complex) and physiologic stage (A-D)
- Participants
- 1,984 / 2,448 / 2,847
- Exposure
- Adults with CHD across 3 eras of baseline encounter
- Cohort #1n = 1,984reference
- Cohort #2n = 2,448
- Cohort #3n = 2,847
- Outcome
- HF hospitalization and all-cause mortality
Main finding
As reported in the abstract
- Temporal decrease in all-cause mortality: 12.7 vs 10.6 vs 9.5 per 1,000 patient-years (cohort #1 vs #2 vs #3)
- P < .001
- Temporal increase in HF hospitalization: 6.8 vs 8.4 vs 11.2 per 1,000 patient-years (cohort #1 vs #2 vs #3)
- P < .001
Observational data: associations, not effects.
Further findings
Physiologic stage distribution across eras (cohort #1 vs #2 vs #3)
- Temporal increase in stage C: 17% vs 21% vs 24%
- P < 0.001
- Stage D: 7% vs 8% vs 10%
- P = 0.09
- Temporal decrease in stage A: 39% vs 35% vs 28%
- P < 0.001
Anatomic groups across eras
- No temporal change in anatomic groups
Association with HF hospitalization and all-cause mortality
- CHD physiologic stage (but not anatomic groups) associated with HF hospitalization and all-cause mortality
Original publication
Temporal Changes in Clinical Characteristics and Outcomes of Adults With Congenital Heart Disease. Am Heart J. Published 8 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →