Association Between Congenital Heart Disease Complexity, Mental Health Conditions and Opioid Use Disorder
Authors' conclusion
Patients with more complex diagnoses had the lowest OUD/SUD prevalence. Comorbid mood and anxiety disorders were strongly associated with these outcomes.
Study context
- Population
- Congenital heart disease (CHD) patients aged 15 to 64 years, 2012–2022, national medical claims
- Participants
- 73,046 patients
- Exposure
- CHD complexity categories: simple biventricular vs complex biventricular vs single ventricle physiology
- Simple biventricularn = 55,335
- Complex biventricularn = 14,077
- Single ventricle physiologyn = 3,634
- Outcome
- Opioid use disorder (OUD) prevalence
Methodological detailsnational
- National
Main finding
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Overdose and substance use disorders (SUD) prevalence
- Trends in overdose and SUD prevalence were similar
Anxiety and mood disorders
- Simple biventricular and single ventricle patients had increased anxiety and mood disorder prevalence
Original publication
Association Between Congenital Heart Disease Complexity, Mental Health Conditions and Opioid Use Disorder. JACC Adv. Published December 2025. doi:10.
Summarised from the published abstract; every number is checked against it