Temporal patterns of pre- and post-natal target organ damage associated with hypertensive pregnancy: a systematic review
Authors' conclusion
The majority of target organ damage reported during a hypertensive pregnancy remains evident throughout the early and late post-partum period despite variation in blood pressure.
Study context
- Population
- Women with hypertensive pregnancy, from pregnancy to postpartum76 studies (pregnancies)
- Participants
- 1,742,698 pregnancies
- Outcome
- BP trajectories and target organ damage (cardiac, vascular, cerebral, renal)
- Follow-up
- Pregnancy to postpartum
Methodological detailssynthesis without meta-analysis, vote-counting based on direction of effect, Ovid/MEDLINE, EMBASE and ClinicalTrials.gov searched up to February 2023; 7644 articles screened
- Synthesis without meta-analysis
- Vote-counting based on direction of effect
- Ovid/MEDLINE, EMBASE and ClinicalTrials.gov searched up to February 2023; 7644 articles screened
Pooled result
As reported in the abstract
- LV hypertrophy, white matter lesions, proteinuria and retinal microvasculature changes first evident during hypertensive pregnancy
- Cardiac, cerebral and retinal changes also reported early and late postpartum despite reduction in BP early postpartum
- Cognitive dysfunction first reported late postpartum
- Only higher quality studies used for final analysis
Original publication
Temporal patterns of pre- and post-natal target organ damage associated with hypertensive pregnancy: a systematic review. Eur J Prev Cardiol. Published 22 August 2023. doi:10.
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