Arrhythmias & electrophysiology
Temporal Trends and Lesion Sets for Persistent Atrial Fibrillation Ablation: A Meta-Analysis With Trial Sequential Analysis and Meta-Regression
Authors' conclusion
Overall success rates from PsAF ablation and procedure/fluoroscopy times have improved over time. However, no adjunctive lesion set, in addition to pulmonary vein isolation, has been conclusively demonstrated to be beneficial.
Study context
- Population
- Patients undergoing ablation for persistent AF (persistent atrial fibrillation (PsAF))
- Participants
- 15,424 patients99 studies
- Outcome
- Freedom from AF/atrial tachycardia
- Follow-up
- 12 months
Methodological detailsmeta-regression, trial sequential analysis, cumulative meta-analysis
- Meta-regression
- Trial sequential analysis
- Cumulative meta-analysis
Pooled result
As reported in the abstract
12 months
Pooled freedom from AF/atrial tachycardia after PsAF ablation
48.2%
5% CI, 44.0–52.3
Further pooled results
Temporal trends (meta-regression)
- Freedom from atrial arrhythmia at 12 months improved over time
- Procedure time and fluoroscopy time significantly reduced over time
Adjunctive lesion sets (trial sequential analysis)
- Complex fractionated atrial electrogram ablation ineffective; further study futile
- Posterior wall isolation: insufficient evidence for routine use
Original publication
Temporal Trends and Lesion Sets for Persistent Atrial Fibrillation Ablation: A Meta-Analysis With Trial Sequential Analysis and Meta-Regression. Circ Arrhythm Electrophysiol. Published 17 August 2023. doi:10.
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