Arrhythmias & electrophysiology
Surgical neuromodulation therapies to prevent postoperative atrial fibrillation: A meta-analysis, meta-regression, and trial sequential analysis of randomized controlled trials
Pooled result · POAFResult — go to the resultRisk ratio 0.62 CI 0.48–0.79Authors' conclusion
This meta-analysis found a significant reduction in POAF incidence with implementation of AFP preservation, PCD, and PVI. Epicardial injections were effective only for patients undergoing coronary bypass.
Study context
- Population
- Patients undergoing cardiac surgery in randomized controlled trials of surgical neuromodulation therapiesanterior fat pad (AFP) preservation 7 · pulmonary vein isolation (PVI) 5 · ganglionated plexus ablation 2 · partial cardiac denervation (PCD) 1 · epicardial injections 5
- Participants
- 3,348 patients20 trials
- Comparison
- Surgical neuromodulation therapies to prevent postoperative atrial fibrillation
- Outcome
- POAF
Pooled result
As reported in the abstract
Risk ratio
0.62
CI 0.48–0.79
P < 0.001
SNMT
risk ratio 0.62 (CI 0.48–0.79); P < 0.001
Further pooled results
Hospital stay
- Surgical neuromodulation therapies (SNMTs) also reduced hospital stay
- P = 0.03
Postoperative atrial fibrillation (POAF) with epicardial injections (subgroup)
- Epicardial injections were effective only in patients undergoing coronary surgery
Meta-regression
- All meta-regression analyses were insignificant
Trial sequential analysis
- In the trial sequential analysis, a positive effect for POAF was observed
Original publication
Surgical neuromodulation therapies to prevent postoperative atrial fibrillation: A meta-analysis, meta-regression, and trial sequential analysis of randomized controlled trials. Heart Rhythm. Published 4 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →