Ten-year clinical outcomes of drug-eluting stents with different polymer coating strategies by degree of coronary calcification: a pooled analysis of the ISAR-TEST 4 and 5 randomised trials
Authors' conclusion
At 10 years after PCI with new-generation DES, there was an incremental increase in adverse events by degree of coronary calcification. These detrimental effects do not seem to be impacted by different polymer-coating strategies.
Study context
- Population
- Patients randomised to polymer-free sirolimus-eluting, biodegradable-polymer sirolimus-eluting or permanent-polymer zotarolimus- or everolimus-eluting stents
- Participants
- 4,953 patients6,924 lesions
- Comparison
- Degree of coronary artery calcification (CAC) and drug-eluting stents (DES) polymer-coating strategy
- Outcome
- All-cause mortality, MI, TLR and definite or probable stent thrombosis by degree of CAC and coating strategy
- Follow-up
- 10 years
Methodological detailsindividual patient data, 10-year follow-up
- Individual patient data
- 10-year follow-up
Pooled result
As reported in the abstract
All-cause mortality, TLR, MI, ST by degree of CAC
All-cause mortality
TLR
MI
ST
- All-cause mortality, adjusted p
- P = 0.004
- Target lesion revascularisation (TLR), adjusted p
- P = 0.001
- Myocardial infarction (MI), adjusted p
- P = 0.02
- Stent thrombosis (ST), adjusted p
- P = 0.57
Original publication
Ten-year clinical outcomes of drug-eluting stents with different polymer coating strategies by degree of coronary calcification: a pooled analysis of the ISAR-TEST 4 and 5 randomised trials. EuroIntervention. Published 20 February 2023. doi:10.
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