Acute cardiac care & resuscitationCohort study
The association of depression and patient and resuscitation characteristics with survival after out-of-hospital cardiac arrest: a cohort study
- Retrospective cohort study
Authors' conclusion
Out-of-hospital cardiac arrest patients with depression presented more frequently with unfavourable patient and OHCA characteristics and had reduced chances of survival.
Study context
- Population
- OHCA cases in the AmsteRdam REsuscitation Studies (ARREST) registry, 2008–2018
- Participants
- 5,594 OHCA cases
- Exposure
- Depression vs no depression
- Depressionn = 582
- Outcome
- Survival at 30 days post-OHCA or hospital discharge
Main finding
OHCA survival
Odds ratio
0.65
95% CI 0.51–0.82
Depression vs No depression
OR 0.65 (95% CI 0.51–0.82)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Survival, Utstein comparator group (subgroup) | 0.63 (0.45–0.89) | |
| Survival, patients with return of spontaneous circulation (subgroup) | 0.60 (0.42–0.85) | |
| 0.512Odds ratio (log scale) |
Mediation of the association
- Mediated by initial rhythm
- 27%
- Mediated by bystander CPR
- 7%
- partial mediation
Original publication
The association of depression and patient and resuscitation characteristics with survival after out-of-hospital cardiac arrest: a cohort study. Europace. Published 6 August 2024. doi:10.1093/europace/euae209
Summarised from the published abstract; every number is checked against it