Arrhythmias & electrophysiology
The Association of Malignancy With Stroke and Bleeding in Atrial Fibrillation: A Population-Based Cohort Study
Authors' conclusion
People with AF and malignancy generally had similar hazards of stroke but higher hazards of bleeding compared with cancer-free control subjects
Study context
- Population
- People aged ≥66 years with newly diagnosed atrial fibrillation (AF)matched n = 43,802
- Participants
- 199,710 people
- Exposure
- Prior malignancy vs cancer-free controls
- Malignancyn = 21,901
- Outcome
- Hospitalization for stroke; hospitalization/ED visits for bleeding
Methodological detailsmatched cohort, administrative datasets
- Matched cohort
- Administrative datasets
Main finding
As reported in the abstract
Malignancy vs Cancer-free controlsHazard ratio (95% CI)
Stroke
1.01(0.88–1.15)
Bleeding
1.45(1.37–1.53)
Observational data: associations, not effects.
Further findings
Stroke and bleeding by cancer type (subgroups)
- Mostly consistent; increased stroke hazard in lung cancer; no increased bleeding hazard in breast cancer and lymphoma
Prior malignancy prevalence
- Prior malignancy among AF patients
- 24,991 (12.5%)
- Malignancy associated with more inpatient AF diagnoses and less anticoagulation
Original publication
The Association of Malignancy With Stroke and Bleeding in Atrial Fibrillation: A Population-Based Cohort Study. JACC CardioOncol. Published 14 January 2025. doi:10.
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