Aortic & peripheral vascular disease
The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque: A Cohort Study in China
Authors' conclusion
CumAIP independently increased the risk of carotid plaque. Discordantly high cumAIP, rather than TG or HDL-C alone, poses a greater risk. Maintaining healthy AIP levels over time may be crucial for preventing atherosclerotic disease.
Study context
- Population
- Participants from the Beijing Health Management Cohortfollowed up until December 31, 2021
- Participants
- 9,202 participants
- Exposure
- Association between atherogenic index of plasma (AIP) and carotid plaque
- Outcome
- Carotid plaque incidence
- Follow-up
- Median 3.99 years
Methodological detailsexternal validation in the Atherosclerosis Risk in Communities study
- External validation in the Atherosclerosis Risk in Communities study
Main finding
As reported in the abstract
Participants developed carotid plaque
2,879
Observational data: associations, not effects.
Further findings
Carotid plaque
| HR (95% CI) | ||
|---|---|---|
| Highest quartile of cumAIPIncreased risk; adjusted Cox proportional hazards model | 1.55 (1.36–1.76) | |
| 0.512Hazard ratio (log scale) |
Carotid plaque, discordance analysis
| HR (95% CI) | ||
|---|---|---|
| Low TG/high cumAIP groupElevated risk · median used as the cutoff | 1.26 (1.10–1.45) | |
| High HDL-C/high cumAIP groupElevated risk · median used as the cutoff | 1.23 (1.09–1.39) | |
| 0.512Hazard ratio (log scale) |
Original publication
The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque: A Cohort Study in China. JACC Adv. Published 12 August 2025. doi:10.
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