Heart failure & cardiomyopathies
The diagnostic yield of an elaborate workup for comorbidities in a real-life heart failure with preserved ejection fraction outpatient population
Authors' conclusion
This study highlights the value of routine comorbidity screening in HFpEF, identifying one new comorbidity per patient on top of three pre-existing conditions, most commonly sleep apnoea or iron deficiency. Treatment of existing comorbidities was often suboptimal.
Study context
- Population
- HFpEF patients diagnosed via a specialized outpatient clinicage 75 ± 7 years, 67% female
- Participants
- 501 patients
- Outcome
- Diagnostic yield of standardized routine workup for comorbidities (laboratory testing, sleep apnoea screening, 24 h Holter, spirometry, exercise testing, 6 min walk test)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Comorbidities per patient
- Known comorbidities before workup, median [IQR]
- three [2-5]
- Additional comorbidities diagnosed during workup
- one
- Newly diagnosed sleep apnoea
- 33%
- Newly diagnosed iron deficiency
- 35%
Observational data: associations, not effects.
Further findings
Overall prevalence of comorbidities
- Hypertension
- 74%
- Sleep apnoea
- 52%
- AF
- 50%
- Iron deficiency
- 49%
- Obesity
- 45%
Pre-existing comorbidities without optimal guideline-directed therapy
- Diabetes
- 23%
- Hypercholesterolaemia
- 36%
- Obesity
- 45%
Original publication
The diagnostic yield of an elaborate workup for comorbidities in a real-life heart failure with preserved ejection fraction outpatient population. Eur J Prev Cardiol. Published 10 July 2025. doi:10.
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