Heart failure & cardiomyopathies
The Different Risk of New-Onset, Chronic, Worsening, and Advanced Heart Failure: A Systematic Review and Meta-Regression Analysis
Authors' conclusion
Our meta-analysis of observational studies confirms the different risk for adverse outcomes across the distinct HF stages.
Study context
- Population
- Heart failure (HF) patients in observational studies, 2012–2022
- Participants
- 862,046 patients66 studies
- Comparison
- New-onset HF vs chronic HF (CHF) vs worsening HF (WHF) vs advanced HF
- Outcome
- 30-day and 1-year all-cause mortality, and 1-year HF hospitalization
- Follow-up
- 30 days and 1 year
Methodological detailsrandom effects meta-analysis, mixed-effects meta-regression
- Random effects meta-analysis
- Mixed-effects meta-regression
Pooled result
As reported in the abstract
1-year all-cause mortality
Further pooled results
| Outcome | New-onset HF | WHF | P value |
|---|---|---|---|
| 30-day all-cause mortality (hospital-admitted) · 30 daysNew-onset HF vs WHF · no significant distinction | 10.13% | 8.11% | P = 0.10 |
1-year HF readmission
- Followed a similar trend
Original publication
The Different Risk of New-Onset, Chronic, Worsening, and Advanced Heart Failure: A Systematic Review and Meta-Regression Analysis. Eur J Heart Fail. Published 24 November 2023. doi:10.
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