Arrhythmias & electrophysiology
The Efficacy of Left Atrial vs Biatrial Cardioneuroablation in Patients With Vasovagal Syncope: A Randomized Clinical Trial
Authors' conclusion
The LA approach's efficacy was noninferior to the BiA approach, whereas the LA approach showed the added benefit of reduced procedure time, a smaller ablation lesion, and smaller x-ray dosage. (Different Catheter Ablation Strategy in Vasovagal Syncope; NCT05573178).
Study context
- Population
- Patients with vasovagal syncopeenrolled, 40 participants in each group
- Participants
- 80 patients
- Comparison
- Left atrial (LA) vs bilateral atrial (BiA) ganglion plexus ablation
- LAn = 40
- BiAn = 40
Methodological details1:1 ratio
- 1:1 ratio
Primary result
As reported in the abstract
Efficacy
P = 0.723
Further findings
Presyncope recurrence rate · 12 months · no significant difference
P = 0.498
Response to head-up tilt test · 12 months · no significant difference
P = 0.664
| Outcome | LA | BiA | Estimate | P value |
|---|---|---|---|---|
| Procedure timeLower with LA | reduction in average 13 minutes (95% CI 6–20) | |||
| X-ray dosageLower with LA | reduction in average 5.7 mGy (95% CI 2.1–9.3) | |||
| Ablation lesionsLower with LA | reduction in average 4 (95% CI 2–6) | |||
| Ablation timeLower with LA | reduction 125 seconds (95% CI 60–190) | |||
| Quality of life · 12 monthsNo significant difference | 78.7 ± 13.6 | 80.9 ± 10.6 | P = 0.417 | |
| Mean heart rate · 12 monthsNo significant difference | 79 ± 11 | 77 ± 9 | P = 0.391 |
Original publication
The Efficacy of Left Atrial vs Biatrial Cardioneuroablation in Patients With Vasovagal Syncope: A Randomized Clinical Trial. JACC Clin Electrophysiol. Published 19 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →