Arrhythmias & electrophysiology
Simplified 3-ganglionated plexus ablation for the treatment of recurrent vasovagal syncope and functional bradyarrhythmia
Authors' conclusion
A simplified 3-GP ablation strategy resulted in similar autonomic denervation and clinical outcomes compared with an extended ablation approach.
Study context
- Population
- Patients with recurrent VVS, extrinsic atrioventricular block (AVB), or sinus node dysfunction (SND) undergoing cardioneuroablation
- Participants
- 58 patients
- Exposure
- Simplified 3-GP ablation strategy vs extensive ablation approach
- Outcome
- Relative HR increase after the atropine test; syncope or pacemaker-free survival
- Follow-up
- Baseline and 6 months; 19.1 (9.2-26.8) months
Main finding
As reported in the abstract
Syncope or pacemaker-free survival
log-rank P = .467
| Outcome | Group A | Group B | P value |
|---|---|---|---|
| Relative HR increase following CNA | 9.9% [4.1-19.0] | 5.6% [2.8-8.4] | P = 0.069 |
| Relative HR increase at 6 months | 24.8% [15.0-37.2] | 19.9% [16.8-25.4] | P = 0.277 |
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Procedural time and fluoroscopy timeGroup A vs group B · procedural time significantly shorter in the only 3-GP group | P = 0.036 |
| Procedural time and fluoroscopy timeGroup A vs group B | P = 0.015 |
- Procedural time and fluoroscopy time: fluoroscopy time significantly shorter in the only 3-GP group
HR variability parameters and autonomic functional tests
- No significant differences in most HR variability parameters or autonomic functional tests
SF-36 quality-of-life score
- Significant improvement in both groups, physical function
- P < 0.001
- Significant improvement in both groups, health change
- P < 0.001
Original publication
Simplified 3-ganglionated plexus ablation for the treatment of recurrent vasovagal syncope and functional bradyarrhythmia. Heart Rhythm. Published 30 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it