Aortic & peripheral vascular disease
The Genetic Determinants of Aortic Distention
Authors' conclusion
Genetic determinants of aortic function influence risk for stroke and coronary artery disease and may lead to novel targets for medical intervention.
Study context
- Population
- UK Biobank participants with CMR imaging
- Participants
- 42,342 participants
- Outcome
- Epidemiologic correlates and genetic determinants of aortic distensibility and strain
Methodological detailsUK Biobank, deep learning CMR quantification
- UK Biobank
- Deep learning CMR quantification
Main finding
As reported in the abstract
- Descending aortic distensibility vs future stroke, HR per SD
- 0.59
- P for association of descending aortic distensibility with stroke
- P = 0.00031
- Heritability of aortic distensibility
- 22% to 25%
- Heritability of aortic strain
- 30% to 33%
- Loci for ascending aortic distensibility
- 12
- Loci for ascending aortic strain
- 26
- Loci for descending aortic distensibility
- 11
- Loci for descending aortic strain
- 21
- Newly identified loci not significantly associated with thoracic aortic diameter
- 22
Further findings
Polygenic scores for aortic strain and distensibility predicting CV outcomes
- Delaying or accelerating disease onset per SD change in scores (modest effect sizes)
- 2%-18%
- Remained statistically significant predictors after accounting for aortic diameter polygenic scores
Original publication
The Genetic Determinants of Aortic Distention. J Am Coll Cardiol. Published 11 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →