Prevention & lipidsCross-sectional study
The gut microbiome across the cardiovascular risk spectrum
- Cross-sectional study
Authors' conclusion
We identified four microbial species showing a gradual trend in abundance from low-risk individuals to those with STEMI, and observed differential abundant species and pathways in STEMI patients compared to those without clinically manifest CAD.
Study context
- Population
- Individuals without clinically manifest coronary artery disease (CAD) at different CV risk levels and patients with ST-elevation myocardial infarction (STEMI)
- Participants
- 411 faecal samples
- Exposure
- Gut microbiome across Framingham CV risk levels and STEMI
- Low riskn = 130reference
- Intermediate riskn = 130
- High riskn = 125
- STEMIn = 26
- Outcome
- Gut microbiome (metagenomics): diversity, differential abundance of species and functional pathways
Main finding
As reported in the abstract
Gut microbiome species and pathways
Species differently abundant among the groups
8
Predicted metabolic pathways differently abundant among the groups
49
Observational data: associations, not effects.
Original publication
The gut microbiome across the cardiovascular risk spectrum. Eur J Prev Cardiol. Published 7 December 2023. doi:10.1093/eurjpc/zwad377
Summarised from the published abstract; every number is checked against it