The gut microbiota and coronary artery calcification in Japanese men
Authors' conclusion
The gut microbiota significantly differed from the phylum to genus level in a manner that was dependent on CAC scores, even before the onset of CAD.
Study context
- Population
- Japanese men (mean age 68.4 years, 46–83 years) undergoing CT and gut microbiology tests
- Participants
- 663 men
- Exposure
- Gut microbiota across coronary artery calcification (CAC) score categories
- CAC = 0n = 219reference
- 0 <CAC ≤100n = 200
- 100 <CACn = 193
- Coronary artery disease (CAD) historyn = 51
- Outcome
- Firmicutes to Bacteroidota ratio
Methodological details16S rRNA gene sequencing (MiSeq); QIIME2 and LEfSe analysis; CAC by Agatston method
- 16S rRNA gene sequencing (MiSeq); QIIME2 and LEfSe analysis; CAC by Agatston method
Main finding
As reported in the abstract
CAC = 0
1.50
median
0 <CAC ≤100
1.52
median
100 <CAC
1.67
median
CAD history
1.80
median
- Difference across 4 CAC categories
- P = 0.020
- 1 SD higher phylum Firmicutes, class Bacilli, order Lactobacillales associated with higher risk of CAD (fold)
- 1.3- to 1.4
Observational data: associations, not effects.
Original publication
The gut microbiota and coronary artery calcification in Japanese men. Am Heart J. Published 5 October 2023. doi:10.
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