Valvular & structural heart disease
The impact of atrial fibrillation on prognosis in aortic stenosis
Authors' conclusion
Patients with significant AS and AF have a reduced survival as compared to patients with SR. Nonetheless, when correcting for markers of LV diastolic function, AF was not independently associated with outcomes in patients with significant AS.
Study context
- Population
- Patients with first diagnosis of significant aortic stenosis (AS)1,182 died
- Participants
- 2,849 patients
- Exposure
- Atrial fibrillation (AF) vs sinus rhythm
- AFn = 686
- Outcome
- All-cause mortality
Main finding
As reported in the abstract
10 years
AF vs SRHazard ratio (95% CI)P value
Univariable Cox
1.42(1.25–1.62)
P < 0.001Multivariable Cox
1.19(1.02–1.38)
P = 0.026Observational data: associations, not effects.
Original publication
The impact of atrial fibrillation on prognosis in aortic stenosis. Eur Heart J Qual Care Clin Outcomes. Published 20 January 2023. doi:10.
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