Arrhythmias & electrophysiology
The Impact of Frailty on Patients With Atrial Fibrillation (AF) and HFrEF Undergoing Catheter Ablation: A Nationwide Population Study
Authors' conclusion
Frailty is associated with worse outcomes in patients with HFrEF undergoing CA for AF.
Study context
- Population
- Patients with AF and HFrEF undergoing Catheter Ablation (CA), US Nationwide Inpatient Sample, January 2016 to December 2019
- Participants
- 113,115 weighted admissions
- Exposure
- Frail vs nonfrail patients
- Frailn = 11,725
- Outcome
- Prevalence of frailty and its influence on CV mortality and discharge disposition
Methodological detailsNationwide Inpatient Sample, multivariable regression analysis
- Nationwide Inpatient Sample
- Multivariable regression analysis
Main finding
As reported in the abstract
Frailty prevalence; in-hospital outcomes
Frail
10.4%
11,725 of 11,725
Frail vs NonfrailAdjusted odds ratio (95% CI)P value
All-cause in-hospital mortality
2.64(1.87–3.72)
P < 0.001Nonhome discharge
3.31(2.78–3.94)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| MACE | 2.00 (1.62–2.47) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
Hospital length of stay · adjusted by Poisson regression
coefficient 0.53 (0.46–0.59) · P < 0.001
Age
- Hospital length of stay: unadjusted P < 0.001
- Age: P < 0.001
Original publication
The Impact of Frailty on Patients With AF and HFrEF Undergoing Catheter Ablation: A Nationwide Population Study. JACC Adv. Published 7 November 2024. doi:10.
Summarised from the published abstract; every number is checked against it