Arrhythmias & electrophysiology
Association of frailty with outcomes of patients undergoing transvenous lead removal for cardiac implantable electronic device infections in the United States
Main finding · In-hospital mortalityResult — go to the resultAdjusted odds ratio 1.95 95% CI 1.74–2.21Authors' conclusion
Frailty is a key predictor of adverse outcomes in TLR for CIED infections.
Study context
- Population
- Patients hospitalized with cardiac implantable electronic device (CIED) infections who underwent transvenous lead removal, US
- Participants
- 44,370 patients
- Exposure
- Frail vs nonfrail patients
- Frailn = 10,116
- Outcome
- In-hospital mortality
Methodological detailsNational Readmissions Database (2016-2021), multivariable logistic regression
- National Readmissions Database (2016-2021)
- Multivariable logistic regression
Main finding
In-hospital mortality
Adjusted odds ratio
1.95
95% CI 1.74–2.21
Events by group
Frail vs Nonfrail
adjusted OR 1.95 (95% CI 1.74–2.21)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Periprocedural complications (cardiac arrest, pulmonary complications) and length of stay
- Frailty independently associated with more periprocedural complications and longer hospital stays
Non-home discharge and readmissions at 30, 90 and 180 days
- Higher rates in frail patients
- P < 0.01 for all
Predictors of mortality
- Malnutrition and decubitus ulcers strongly associated with mortality
Original publication
Association of frailty with outcomes of patients undergoing transvenous lead removal for cardiac implantable electronic device infections in the United States. Heart Rhythm. Published 22 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it