Valvular & structural heart disease
The Impact of Gender and Frailty on the Outcome of Older Patients with Functional Mitral Regurgitation
Authors' conclusion
Despite better left ventricular systolic function, mortality in medically treated older female patients suffering from functional mitral regurgitation is not lower than in males. In this real-world cohort, frailty was a stronger predictor of clinical outcome than gender.
Study context
- Population
- Older patients (≥65 years) with medically treated moderate to severe functional mitral regurgitation (MR), 2014 to 2020
- Participants
- 243 patients
- Exposure
- Female vs male patients
- Outcome
- Combined HF hospitalization and all-cause death
- Follow-up
- 1 year
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
P = 0.61
- Being female not associated with primary endpoint, univariate Cox HR
- 0.87; P = 0.54 (95% CI 0.55 to 1.37)
Observational data: associations, not effects.
Further findings
All-cause mortality · 1 year
P = 0.69
| Outcome | Males | Females | P value |
|---|---|---|---|
| Baseline EF | 39% (SD 16) | 48% (SD 14) | P < 0.001 |
Original publication
The Impact of Gender and Frailty on the Outcome of Older Patients with Functional Mitral Regurgitation. ESC Heart Fail. Published 24 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →