Valvular & structural heart disease
Sex differences and long-term clinical outcomes after transcatheter aortic valve replacement: A SWEDEHEART study
Main finding · All-cause mortality (cumulative incidence)Result — go to the resultAbsolute difference 6.4 % 95% CI 4.4%–8.4%Authors' conclusion
Females had a higher survival rate and a lower bleeding risk than males after TAVR.
Study context
- Population
- All patients undergoing transcatheter aortic valve replacement (TAVR) in Sweden, 2008–2022 (mean age 81 years)mean follow-up 3.1 years
- Participants
- 10,475 patients
- Exposure
- Females vs males after TAVR
- Femalen = 4,886
- Malen = 5,589reference
- Outcome
- All-cause mortality
- Follow-up
- 10 years
Methodological detailsSWEDEHEART register, regression standardization
- SWEDEHEART register
- Regression standardization
Main finding
All-cause mortality (cumulative incidence) · 1, 5 and 10 years
Absolute difference
6.4 %
95% CI 4.4%–8.4%
By group
Female
- 1 year
- 8%
- 5 years
- 38%
- 10 years
- 75%
Male
- 1 year
- 10%
- 5 years
- 45%
- 10 years
- 82%
1 year
Female8%
Male10%
5 years
Female38%
Male45%
10 years
Female75%
Male82%
Female vs Male
absolute difference 6.4 % (95% CI 4.4%–8.4%)
As reported in the abstract
Observational data: associations, not effects.
Further findings
HF, MI, stroke, reintervention
- No difference between the sexes
Safety
| Outcome | Absolute survival difference (%) (95% CI) | |
|---|---|---|
| Major bleeding · 10 years · lower risk in females | 4.0 (1.9%–6.2%) | |
| −50510Difference, % (linear scale) |
Original publication
Sex differences and long-term clinical outcomes after transcatheter aortic valve replacement: A SWEDEHEART study. Am Heart J. Published 10 August 2024. doi:10.
Summarised from the published abstract; every number is checked against it