The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation
Authors' conclusion
The MIDA Score may represent an innovative tool for DMR management, being able to position a given patient within a continuous spectrum of short- and long-term mortality risk, either under medical or surgical management.
Study context
- Population
- Patients with pure, isolated degenerative mitral regurgitation (DMR) consecutively diagnosed by echocardiography at tertiary European/North/South-American centresMIDA registries
- Participants
- 3,666 patients
- Comparison
- Derivation vs Validation
- Derivationn = 2,472
- Validationn = 1,194
- Outcome
- Total mortality post-diagnosis (MIDA Score, range 0–12, discrimination)
Methodological detailsmulticentre, international registries
- Multicentre
- International registries
Performance
As reported in the abstract
Concordance of MIDA Score for total mortality
| Test or model | C |
|---|---|
| Derivation | 0.78 |
| Validation | 0.81 |
C
Derivation0.78
Validation0.81
Further findings
1-year mortality by MIDA Score (whole MIDA population)
- Medical management, Scores 0, 7-8, 11-12
- 0.4, 17, and 48%
- After surgery, Scores 0, 7-8, 11-12
- 1, 7, and 14%
- P < 0.001
5-year survival by MIDA Score (whole MIDA population)
- Medical management, Scores 0, 7-8, 11-12
- 98 ± 1, 57 ± 4, and 21 ± 10%
- After surgery, Scores 0, 7-8, 11-12
- 99 ± 1, 82 ± 2, and 57 ± 9%
- P < 0.001
Incremental prognostic information over guideline markers and EuroScoreII
- MIDA Score provided incremental prognostic information
- P ≤ 0.002
Original publication
The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation. Eur Heart J. Published 13 August 2017. doi:10.
Summarised from the published abstract; every number is checked against it