The Optimal Definition and Prediction Nomogram for Left Ventricular Remodelling After Acute Myocardial Infarction
Authors' conclusion
LV remodelling defined by LVEDV, LVESV and LVEF were independent predictors for long-term mortality or heart failure hospitalization in AMI patients after percutaneous coronary intervention. However, only remodelling defined by LVEF was suitable for predicting all-cause death. In addition, the nomogram can provide an accurate and effective tool for the prediction of postinfarct remodelling.
Study context
- Population
- Acute myocardial infarction (AMI) patients undergoing PCI, January 2015 to January 2020
- Participants
- 829 patients
- Exposure
- Left ventricular (LV) remodelling definitions for prognosis
- LV end-diastolic volume (LVEDV)n = 206
- LV end-systolic volume (LVESV)n = 238
- LV ejection fraction (LVEF)n = 121
- Outcome
- LV remodelling and its association with long-term outcomes (composite endpoint, mortality)
- Follow-up
- 6 months after infarction
Methodological detailsprediction nomogram
- Prediction nomogram
Main finding
As reported in the abstract
Incidence of LV remodelling by definition · 6 months
Observational data: associations, not effects.
Further findings
Long-term mortality, LV remodelling defined by LVEF
| HR (95% CI) | P value | ||
|---|---|---|---|
| LVEFOnly LVEF definition significantly associated with mortality | 2.78 (1.41–5.48) | P = 0.003 | |
| 0.20.5125Hazard ratio (log scale) |
Remodelling prediction nomogram (7 variables: DBP, heart rate, AMI type, stent length, NT-proBNP, troponin I, glucose)
- AUC
- 0.766
- Calibration and decision curves indicated consistency and better net benefit
Original publication
The Optimal Definition and Prediction Nomogram for Left Ventricular Remodelling After Acute Myocardial Infarction. ESC Heart Fail. Published 24 July 2023. doi:10.
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