Heart failure & cardiomyopathies
The Potential Predictive Value of Cardiac Mechanics for Left Ventricular Reverse Remodelling in Dilated Cardiomyopathy
Authors' conclusion
Patients with LVRR had a lower LV volume index, lower LVSV index, lower LGE extent, higher LVRI, and preserved myocardial deformation in the longitudinal direction at baseline. LVRI and rGLPS at baseline were independent determinants of LVRR.
Study context
- Population
- Initially diagnosed dilated cardiomyopathy (DCM) patients undergoing baseline cardiac magnetic resonance (CMR) and echocardiography35 (36%) achieved left ventricular reverse remodelling (LVRR)
- Participants
- Nighty-eight participants
- Comparison
- Baseline CMR parameters in patients with vs without LVRR
- LVRRn = 35
- Outcome
- Independent CMR predictors of LV reverse remodelling (multivariate logistic regression)
- Follow-up
- Median 9 [IQR 7-12] months
Performance
As reported in the abstract
Independent predictors of LVRR
Odds ratio (95% CI)P value
LVRI (per SD)
1.79(1.08–2.98)
P = 0.024rGLPS (per SD)
1.88(1.18–3.01)
P = 0.008Per SD, as printed
Further findings
| Outcome | LVSVi + LVRI + rGLPS | LVSVi + LVRI | P value |
|---|---|---|---|
| Discrimination for LVRR (AUC)DeLong test; not significant | P = 0.09 | ||
| AUC | 0.75 | 0.68 |
Baseline differences, LVRR vs no LVRR
- LVRR: lower left ventricular (LV) volume, mass, LGE extent and LVSVi; higher left ventricular remodelling index (LVRI), longitudinal nStrains, rStrains and peak systolic strain rate (PSSR), and circumferential rStrains
- all P < 0.05
Original publication
The Potential Predictive Value of Cardiac Mechanics for Left Ventricular Reverse Remodelling in Dilated Cardiomyopathy. ESC Heart Fail. Published 12 September 2023. doi:10.
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