The prognostic effect of prediabetes defined by different criteria in patients with stable coronary artery disease: a prospective cohort study in Asia
Authors' conclusion
This study supports the use of WHO/IEC criteria for the identification of prediabetes in stable CAD patients.
Study context
- Population
- Non-diabetic patients with stable coronary artery disease (CAD), Asia
- Participants
- 4,088 patients
- Exposure
- Prediabetes vs normoglycaemia
- Outcome
- MACE:
- All-cause death
- MI
- Stroke
- Follow-up
- Median 3.2 years
Methodological detailsconsecutive enrolment
- Consecutive enrolment
Main finding
As reported in the abstract
Each group vs normoglycaemiaAdjusted hazard ratio (95% CI)
WHO/IEC-defined prediabetesmainly driven by HbA1c-defined prediabetes
1.50(1.10–2.06)
ADA-defined prediabetes
1.17(0.81–1.68)
Observational data: associations, not effects.
Further findings
| Outcome | WHO/IEC-defined prediabetes | ADA-defined prediabetes |
|---|---|---|
| Prevalence of prediabetes | 34% | 67% |
Risk prediction for major adverse cardiovascular event (MACE) by FPG and HbA1c
- Optimal HbA1c cutoff for predicting MACE
- 5.85%
- FPG not associated with CV events; HbA1c improved MACE risk prediction over traditional risk factors
Original publication
The prognostic effect of prediabetes defined by different criteria in patients with stable coronary artery disease: a prospective cohort study in Asia. Eur J Prev Cardiol. Published 29 March 2023. doi:10.
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