Valvular & structural heart disease
The Prognostic Value of Right Ventricle–Pulmonary Artery Coupling in Valve Interventions: Systematic Review and Meta-Analysis
Authors' conclusion
TAPSE/PASP is an independent predictor of outcomes after interventions for AS and MR.
Study context
- Population
- Patients undergoing intervention for aortic stenosis (AS), mitral regurgitation (MR) or tricuspid regurgitation (TR)
- Participants
- 12,992 patients · 30 studies
- Comparison
- Reduced vs preserved tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP)
- ASn = 6,100
- MRn = 5,032
- TRn = 1,860
- Outcome
- All-cause mortality
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
All-cause mortality with reduced TAPSE/PASP
Adjusted hazard ratio (95% CI)P value
AS
1.69(1.30–2.20)
P < 0.001MR
1.94(1.40–2.69)
P < 0.001Further pooled results
Composite major adverse cardiovascular events (MACE) with reduced TAPSE/PASP
| Comparison | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| AS | 1.60 (1.29–2.00) | P < 0.001 | |
| MR | 2.01 (1.54–2.62) | P < 0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
| Outcome | AS | MR | TR | Estimate | P value |
|---|---|---|---|---|---|
| Optimal TAPSE/PASP threshold to predict all-cause mortality | ≤0.51 mm/mm Hg | ≤0.33 mm/mm Hg | ≤0.44 mm/mm Hg |
Nonlinear association of TAPSE/PASP with adverse outcomes
- Significant nonlinear associations in AS and MR
- P < 0.001
Original publication
The Prognostic Value of Right Ventricle–Pulmonary Artery Coupling in Valve Interventions: Systematic Review and Meta-Analysis. JACC Cardiovasc Interv. Published 15 December 2025. doi:10.
Summarised from the published abstract; every number is checked against it