Congenital heart diseaseResearch article
The Proteomic Profile of Adults With a Fontan Circulation
- Proteomic profiling study
- age/sex-matched control participants
Authors' conclusion
The plasma proteome in adults with a Fontan circulation is markedly different from the proteome of biventricular controls, with widespread perturbations across metabolic, inflammatory, and organ-specific pathways. This hypothesis-generating, foundational work suggests that broad-based proteomics may help identify mechanisms of compensation and deterioration in this poorly understood population.
Study context
- Population
- Adults with a Fontan circulation and control participants without known cardiovascular disease162 adults with a Fontan circulation and 36 age/sex-matched controls enrolled · Fontan (enrolled) 162 · Control (enrolled) 36 · Olink platform 192 · SomaLogic platform 85
- Participants
- 162 vs 36
- Comparison
- Plasma proteome between the Fontan and control groups
- Fontann = 162
- Controln = 36
Main finding
As reported in the abstract
Olink proteomics platform (975 proteins)
331 (33.9%)
SomaLogic proteomics platform (1,265 proteins)
501 (39.6%)
Further findings
Proteins consistently among the 30 most differentially expressed on both platforms (491 proteins measured by both)
- angiopoietin-2, contactin-5, insulin-like growth factor-binding protein 7, thrombospondin-2, and tartrate-resistant acid phosphatase type 5
- 5
Association of proteomic signatures with organ perturbations
- Proteomic signatures in the Fontan circulation were associated with cardiac and renal perturbations, even before clinical evidence of end-organ failure
Original publication
Summarised from the published abstract; every number is checked against it