Association of Fontan Pathophysiology With Plasma Bile Acids
Authors' conclusion
Elevated BAs are associated with worsening Fontan physiology. These findings warrant further exploration.
Study context
- Population
- Patients with Fontan circulation and age- and sex-matched healthy controlsFontan patients Twenty · healthy controls 20
- Comparison
- Patients with Fontan circulation were compared to age- and sex-matched healthy controls
- Fontan patientsn = Twenty
- Healthy controlsn = 20
- Outcome
- Body composition, frailty, cardiopulmonary exercise testing and hemodynamics
Methodological detailsage- and sex-matched healthy controls
- Age- and sex-matched healthy controls
Main finding
As reported in the abstract
- Fontan patients had significantly lower skeletal muscle mass, took longer to complete the 5 times sit-to-stand test; achieved lower %VO2 max, and had lower resting and postexercise hemodynamic parameters
Further findings
Nontargeted metabolomics
- Elevated bile acid (BAs), oxylipins, and leucine metabolites in Fontan patients
Targeted plasma BA
- Total BA as well as 17 BA components were markedly elevated in the Fontan patients
Associations of selective BAs
- Selective BAs were negatively associated with age, degree of frailty, cardiopulmonary function, and hemodynamic parameters
Original publication
Association of Fontan Pathophysiology With Plasma Bile Acids. JACC Adv. Published 18 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it