Arrhythmias & electrophysiology
The Ratio of Cytochrome C Oxidase Subunit 4 Isoform 4I1 and 4I2 mRNA is Changed in Permanent Atrial Fibrillation
Authors' conclusion
This study describes a possible molecular correlate for the development of AF. Due to the known functional significance of COX 4I2, mitochondrial dysfunction can be assumed as a part of the pathogenesis of AF.
Study context
- Population
- Patients with right atrial myocardial biopsies (permanent atrial fibrillation (AF) or SR); HeLa 53 cells under hypoxia in vitro
- Participants
- 11 vs 31
- Comparison
- Permanent AF vs sinus rhythm
- AFn = 11
- SRn = 31reference
- Outcome
- COX 4I2/4I1 mRNA expression ratio (right atrial biopsies)
Methodological detailsin vitro and ex vivo
- In vitro and ex vivo
Main finding
As reported in the abstract
4I2/4I1 mRNA expression ratio increased in permanent AF, with decreased COX 4I1 expression
0.630 to 1.058
Original publication
The Ratio of Cytochrome C Oxidase Subunit 4 Isoform 4I1 and 4I2 mRNA is Changed in Permanent Atrial Fibrillation. ESC Heart Fail. Published 27 December 2023. doi:10.
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