Cohort study
The role of remnant cholesterol in patients with ST-segment elevation myocardial infarction
- Cohort study
- consecutive patients
Authors' conclusion
In patients with STEMI treated with primary PCI, elevated RC levels beyond LDL-C and discordantly high RC were independently associated with increased all-cause mortality.
Study context
- Population
- Consecutive patients with STEMI treated with primary percutaneous coronary intervention (PCI), 1999–2016
- Participants
- 6,602 patients
- Exposure
- Discordantly high remnant cholesterol (RC) vs discordantly low RC
- Discordantly low RCn = 2,441reference
- Concordantn = 1,651
- Discordantly high RCn = 2,510
- Outcome
- All-cause mortality, CV death, ischaemic stroke and recurrent myocardial infarction (MI)
- Follow-up
- Median 6.0 years
Main finding
As reported in the abstract
All-cause mortality and CV death
Discordantly high RC
31.87%
Each group vs discordantly low RCEstimate (95% CI)
Discordantly high RCall-cause mortality
adjusted HR 1.55(1.37–1.75)
Discordantly high RCCV death
adjusted HR 1.47(1.25–1.72)
RCadjusted model; all-cause mortality
HR 1.14(1.07–1.22)
Discordantly high RCunadjusted; all-cause mortality
HR 1.82(1.63–2.04)
Discordantly high RCunadjusted; CV death
HR 1.79(1.55–2.06)
Observational data: associations, not effects.
Further findings
Unadjusted analysis
- unadjusted
Original publication
The role of remnant cholesterol in patients with ST-segment elevation myocardial infarction. Eur J Prev Cardiol. Published 6 March 2024. doi:10.1093/eurjpc/zwae102
Summarised from the published abstract; every number is checked against it