The Spatial Ventricular Gradient Is an Independent Predictor of Anthracycline-Associated Cardiotoxicity
Authors' conclusion
Larger SVG magnitude and more leftward SVG orientation were associated with a decreased risk of anthracycline cardiotoxicity in a large retrospective cohort.
Study context
- Population
- Patients treated with anthracyclines for cancer at a single academic medical centre, 1992–2019, with ECG within 6 months before anthracycline initiation71% hematologic malignancies
- Participants
- 889 patients
- Exposure
- Pre-chemotherapy spatial ventricular gradient (SVG) magnitude and orientation
- Outcome
- Anthracycline-associated heart failure (HF) or cardiomyopathy (CM), death as competing risk
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
HF or CM
Subhazard ratio (95% CI)P value
SVG magnitude (per 1 SD increase)multivariable adjusted
0.76(0.59–0.96)
P = 0.024More leftward VGx orientation (per 1 SD increase)
0.77(0.61–0.96)
P = 0.023Per 1 SD increase, as printed
Observational data: associations, not effects.
Original publication
The Spatial Ventricular Gradient Is an Independent Predictor of Anthracycline-Associated Cardiotoxicity. JACC Adv. Published 31 March 2023. doi:10.
Summarised from the published abstract; every number is checked against it