Time-Varying Spatial Ventricular Gradient Orientation Is Associated With Anthracycline Heart Failure
Authors' conclusion
Time-varying SVG azimuth was independently associated with HF risk in patients treated with anthracyclines. Assessing dynamic changes in SVG azimuth during anthracycline treatment may enhance early identification of patients at risk for HF and inform the use of cardioprotective strategies during cancer therapy.
Study context
- Population
- Adult patients with cancer treated with anthracyclines between 1992 to 2019, without prior heart failure (HF)median age 61 years, 48% male
- Participants
- 594 patients
- Exposure
- Time-varying spatial ventricular gradient (SVG) parameters and incident HF
- Outcome
- Incident HF
- Follow-up
- Within 5 years
Methodological detailsmultivariable competing-risks regression with SVG parameters as time-varying covariates, death as a competing outcome
- Multivariable competing-risks regression with SVG parameters as time-varying covariates
- Death as a competing outcome
Main finding
As reported in the abstract
Developed HF within 5 years
83
14%
Time-varying SVG azimuth independently associated with HF
P = 0.0024
Gradient in risk across azimuth values
9.4-fold
Observational data: associations, not effects.
Original publication
Time-Varying Spatial Ventricular Gradient Orientation Is Associated With Anthracycline Heart Failure. JACC Adv. Published 20 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it