The Stanford experience of heart transplantation over five decades
Authors' conclusion
In this half-century retrospective descriptive study from one of the largest heart transplant programmes in the USA, long-term survival after heart transplantation has improved over time despite increased recipient and donor age, worsening comorbidities, increased technical complexity, and prolonged total allograft ischaemia time.
Study context
- Population
- Adult heart transplant recipients at Stanford University, 1968–2020
- Participants
- 1,958 adult heart transplantations
- Exposure
- Heart transplantation 2007-19 vs 1996-2006
- 2007-19n = 515
- 1996-2006n = 356reference
- 1968-95n = 639
- Outcome
- All-cause mortality
Methodological detailssingle-centre, stabilized inverse probability weighting, Follow-up data updated through 2020
- Single-centre
- Stabilized inverse probability weighting
- Follow-up data updated through 2020
Main finding
As reported in the abstract
Survival
Observational data: associations, not effects.
Further findings
| Outcome | 2007-19 | 1996-2006 | 1968-95 | |
|---|---|---|---|---|
| Distance organ travelled (after stabilized IPW) | 159.3 ± 169.9 miles | 84.2 ± 111.1 miles | Not reported in the abstract | 1968-95: not reported in the abstract |
Total allograft ischaemia time (after stabilized IPW)
- Total allograft ischaemia time increased over time
- 199.6 ± 52.7 vs. 225.3 ± 50.0 min
Original publication
The Stanford experience of heart transplantation over five decades. Eur Heart J. Published 1 August 2021. doi:10.
Summarised from the published abstract; every number is checked against it