Arrhythmias & electrophysiology
Thermal side effects during pulsed field ablation: an analysis using computer modelling
Authors' conclusion
Thermal effects from PFA depend on the total energy deposited, with peak voltage being a significant factor. Current commercially available PFA systems have the potential to induce collateral thermal injury with repeated applications of pulsed field energy.
Study context
- Population
- Simulated myocardial and oesophageal tissue (left atrium model)
- Comparison
- Pulsed field ablation (PFA) at peak voltages of 1, 1.5 and 2 kV
- Outcome
- Thermal effects of PFA on myocardial and oesophageal tissue
- Follow-up
- After a single pulse train
Methodological detailsthree-dimensional computer model of the left atrium, bipolar configuration, monophasic waveform, 100 μs pulse width, 1 s gap, 50 pulses
- Three-dimensional computer model of the left atrium
- Bipolar configuration
- Monophasic waveform, 100 μs pulse width, 1 s gap, 50 pulses
Main finding
As reported in the abstract
Oesophageal temperature
| Group | Value | Temperature rise |
|---|---|---|
| 1 kV | Minimal | |
| 1.5 kV | 46.3 °C | |
| 2 kV | >62 °C |
Value
1 kV— not stated in the abstract
1.5 kV46.3 °C
2 kV>62 °C
Temperature rise
1 kVMinimal
1.5 kV— not stated in the abstract
2 kV— not stated in the abstract
Original publication
Thermal side effects during pulsed field ablation: an analysis using computer modelling. Europace. Published 17 February 2025. doi:10.
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