Heart failure & cardiomyopathies
Time to Intravenous Diuretic Administration in Patients Hospitalized with Heart Failure: An Observational Study
Authors' conclusion
In Japan, real-world patterns of intravenous diuretic administration for patients with heart failure remains far from the time-sensitive approach recommended in Japanese, European, and United States guidelines.
Study context
- Population
- Patients hospitalized with HF requiring urgent IV diuretic therapy in Japan
- Participants
- 1,577 patients
- Exposure
- With vs without diuretic modification
- With diuretic modificationn = 437
- Without diuretic modificationn = 1,140reference
- Outcome
- Time from hospital visit to first, second and maximum dose of IV diuretics
Methodological detailsJapanese medical records database
- Japanese medical records database
Main finding
As reported in the abstract
Time from hospital visit to first IV diuretic dose
- IV diuretic received within 1 h of hospital visit
- 43.5% (686/1577)
- IV diuretic received ≤2 h of hospital visit
- 16.4% (258/1577)
- Diuretic modification after first 24 h of hospital visit
- 59.0% (258/437)
- Median time to first dose titration
- 18.6 h
- Median time to first combination diuretic use
- 17.0 h
Observational data: associations, not effects.
Further findings
Duration of IV diuretic use
Length of hospitalization
Repeated IV diuretic administration
In-hospital death
Type of modification among patients with inadequate response after first dose
- IV dose titration
- 42.1%
- Combination diuretics
- 56.5%
- Both
- 1.4%
Duration of IV diuretic use
- Significantly longer with diuretic modification
Repeated IV diuretic administration
- Significantly greater proportion with diuretic modification
Length of hospitalization
- Similar with vs without diuretic modification
In-hospital death
- Similar with vs without diuretic modification
Original publication
Time to Intravenous Diuretic Administration in Patients Hospitalized with Heart Failure: An Observational Study. ESC Heart Fail. Published 6 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →