Tissue-Based Predictors of Impaired Right Ventricular Strain in Coronary Artery Disease: A Multicenter Stress Perfusion Study
Authors' conclusion
RVIS in patients with known coronary artery disease is associated with potentially reversible LV processes, including LV functional impairment due to ischemic and predominantly viable myocardium, which confers increased mortality risk independent of LV function and tissue substrate.
Study context
- Population
- Patients with known CAD undergoing vasodilator stress cardiac magnetic resonance (CMR), 7 sites, May 2005–October 2018
- Participants
- 2,604 patients
- Outcome
- Impaired RV strain (RVIS) by CMR-feature tracking and its tissue-based predictors
Methodological details7 sites
- 7 sites
Main finding
As reported in the abstract
RVIS
18%
461
- RVIS strongly associated with left ventricle (LV) dysfunction (LVEF or wall motion score)
- P < 0.001 for all
- Hibernating myocardium and infarct size each independently associated with RVIS
- both P<0.001
Observational data: associations, not effects.
Further findings
All-cause mortality · median 4.62 [IQR 2.15-7.67] years
| HR (95% CI) | P value | ||
|---|---|---|---|
| RVISAdjusted for LV function, infarction and ischemia | 1.35 (1.11–1.66) | P = 0.003 | |
| 0.512Hazard ratio (log scale) |
- All-cause mortality — Deaths
- 555 (21%)
- All-cause mortality — right ventricular (RV) dysfunction by global longitudinal strain and RVEF each prognostic for all-cause mortality (Kaplan-Meier)
- P<0.001
Original publication
Tissue-Based Predictors of Impaired Right Ventricular Strain in Coronary Artery Disease: A Multicenter Stress Perfusion Study. Circ Cardiovasc Imaging. Published 20 August 2024. doi:10.
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