Valvular & structural heart disease
Traditional and novel risk factors for incident aortic stenosis in community-dwelling older adults
Authors' conclusion
This comprehensive evaluation of risk factors for long-term incidence of AS identified associations for diabetes and prevalent CHD, LpPLA2 activity, sCD14 and IL-6, and eGFRcr.
Study context
- Population
- Community-dwelling older adults, Cardiovascular Health Study
- Participants
- 5,390 adults
- Exposure
- Traditional and novel risk factors for incident aortic stenosis (AS)
- Outcome
- Incident moderate or severe AS (including AS procedures)
- Follow-up
- Median 13.1 years
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Incident moderate/severe AS (287 cases), fully adjusted
Estimate (95% CI)
Age
HR 1.66 per SD(1.45–1.91)
Male sex
HR 1.41(1.06–1.87)
Diabetes
HR 1.53(1.10–2.13)
CHD
HR 1.36(1.01–1.84)
LpPLA2 activity
HR 1.21 per SD(1.07–1.37)
sCD14
HR 1.16 per SD(1.01–1.34)
Black raceinverse association
HR 0.40(0.24–0.65)
Per SD, as printed
Observational data: associations, not effects.
Further findings
Clinically significant AS (severe AS, including procedures; 175 cases)
- Findings similar; Coronary heart disease (CHD) and sCD14 fell short of significance; IL-6 showed a positive association
Original publication
Traditional and novel risk factors for incident aortic stenosis in community-dwelling older adults. Heart. Published 18 July 2023. doi:10.
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