Heart failure & cardiomyopathiesCohort study
Trajectories of Kidney Function in Heart Failure Over a 15-Year Follow-Up
- Prospective cohort study
- prospective observational registry
- consecutive enrolment
Authors' conclusion
These findings highlight the sustained decline in eGFR over 15 years in patients with heart failure, with variations based on clinical characteristics
Study context
- Population
- Ambulatory outpatients with chronic HF, enrolled August 2001–December 202128,634 estimated glomerular filtration rate (eGFR) measurements
- Participants
- 2,672 outpatients
- Outcome
- eGFR trajectory (2009 CKD-EPI equation) and its association with all-cause and CV death
- Follow-up
- ≤15 years
Main finding
As reported in the abstract
eGFR decline, entire cohort · 15 years
eGFR slope, entire cohort
−1.70 (mL/min/1.73 m² per year; 95% CI −1.75 to −1.66)
Observational data: associations, not effects.
Further findings
eGFR decline by clinical characteristics
- More pronounced eGFR decrease in older patients, diabetes, preserved EF, higher baseline eGFR, elevated hospitalization rates and those who died during follow-up
Original publication
Trajectories of Kidney Function in Heart Failure Over a 15-Year Follow-Up. JACC Heart Fail. Published 28 February 2024. doi:10.1016/j.jchf.2024.01.004
Summarised from the published abstract; every number is checked against it