Heart failure & cardiomyopathies
Trajectory Change of Left Ventricular Ejection Fraction After Rhythm Control for Atrial Fibrillation in Heart Failure
Main finding · LVEF trajectory improvementResult — go to the resultHazard ratio 1.671 95% CI 1.196–2.335Authors' conclusion
Rhythm control is associated with improved LVEF trajectory and clinical outcomes
Study context
- Population
- Patients with atrial fibrillation (AF) and heart failure (HF) across the whole HF spectrum (HFpEF, HFmrEF, HFrEF)post-matched cohort
- Exposure
- Rhythm control vs rate control
- Outcome
- LVEF trajectory improvement
Main finding
As reported in the abstract
Hazard ratio
1.671
95% CI 1.196–2.335
P = 0.003
Events by group
Rhythm controlvs Rate control
HR 1.671 (95% CI 1.196–2.335); P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality | 0.600 (0.366–0.983) | P = 0.043 | |
| HF-related admission | 0.611 (0.496–0.753) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Independent predictors of left ventricular ejection fraction (LVEF) trajectory improvement (rhythm control subgroup)
- E/e' OR 0.878 (95% CI 0.792-0.974)
- P = 0.014
- LV end-diastolic diameter OR 0.874 (95% CI 0.777-0.983)
- P = 0.024
- CHA2DS2-VASc score OR 0.647 (95% CI 0.438-0.955)
- P = 0.028
Original publication
Trajectory Change of Left Ventricular Ejection Fraction After Rhythm Control for Atrial Fibrillation in Heart Failure. ESC Heart Fail. Published 14 December 2023. doi:10.
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